Jovclé新植萃
桂花
研究文獻指出桂花毛蕊花苷(Verbascoside)是一種植物多酚，具抗氧化、抗發炎與清除自由基等效果。氧化、發炎與自由基皆能促進基質金屬蛋白酶(MMP)的表達，因此毛蕊花苷(Verbascoside)對於紫外線傷害保護作用相關機制影響。結果指出桂花毛蕊花苷在低濃度下對細胞具增生幫助且有效抑制UV照射導致之細胞傷害，此外也對UV所誘導MMP-1活性與表現有抑制作用，相對當抑制MMP-1表現將協同降低膠原蛋白的損失。本研究顯示桂花毛蕊花苷促進人類真皮層細胞增生作用與抗發炎能力，能有效對UV誘導膠原蛋白損失加以防護。顯示毛蕊花苷能透過改善人類真皮層細胞對UV的保護作用。[1]
本研究顯示從桂花中抽提出的毛蕊花苷能夠產生下列幾項結果；第一、促進人類真皮層細胞增生作用。第二、能對正常皮膚細胞有效減少MMP-1 的誘導路徑發生，低濃度時更能促進細胞內膠原蛋白增生。第三、對UVA 與UVB所產生的細胞光傷害與老化現象，能透過上述機制更進一步產生很好的防護效果。[2]
Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti- Inflammatory Effect. Our results demonstrate that verbascoside could be a potential therapeutic agent for the treatment of AD. (桂花毛蕊花苷透過其有效的抗發炎作用，減輕實驗小白鼠異位性皮膚炎症狀。我們的結果表明，桂花毛蕊花苷可能是治療異位性皮膚炎的潛在治療劑。[3]
出處:
[1]李泓逸（2016）。《毛蕊花苷對皮膚細胞UV傷害保護作用之研究》。台北：國防醫學院生物化學研究所。
[2]張溫良（2020）。《桂花中毛蕊花苷成分對皮膚細胞之活性分析評估報告》。台北：國防醫學院藥學系。
[3]Yongxi Li; Haiyang Yu; Yan Jin; Min Li; Caijie Qu（2018）。《Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti- Inflammatory Effect》Switzerland：KARGER INTERNATIONAL Int Arch Allergy Immunol
積雪草
積雪草(Centella asiatica L.)是繖型科(Apiaceae)積雪草屬(Centella)多年生的草本植物，是台灣民間常見的藥用植物，全草具有活血消腫止痛、清熱解毒利水之功效，已被研究證實能促進皮膚真皮層中成纖維細胞合成及代謝膠原蛋白及玻尿酸，延緩真皮層中老化的發生。水通道蛋白3 (Aquaporin 3, AQP3)是種跨膜轉運蛋白，可以轉運水分、甘油和小分子溶質，參與皮膚表皮層中角質形成細胞分化、增殖及遷移，過去研究得知，AQP3使表皮層增強保濕作用及蓄水能力，可能在皮膚老化扮演重要角色，能作為延緩皮膚老化的新興標的。實驗結果顯示積雪草三萜類化合物能透過增加AQP3提供延緩皮膚老化可能的潛力。[2]
C. asiatica might enhance wound healing resulting from improved angiogenesis. This might occur due to its stimulating effect on collagen I, Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) production. Besides, C. asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and lipoxygenase (LOX) activity. (積雪草可能會因改善血管生成而促進傷口癒合。這可能是由於它對I型膠原蛋白、纖維母細胞生長因子 (FGF)和血管內皮生長因子 (VEGF) 產生的刺激作用。此外，積雪草可透過減少白血球介素1β (IL-1β)、白血球介素6 (IL-6) 和腫瘤壞死因子α (TNFα)、前列腺素E2 (PGE2)、環氧合酶而表現出抗發炎作用)。[3]
出處:
[1]張溫良（2020）。《積雪草三萜類成分對人類角質形成細胞活性分析評估報告》。台北：國防醫學院藥學系。
[2]王宣舜（2021）。《積雪草化學成分及藥理活性之研究》。台北：國防醫學院藥學研究所。
[3]Elena Arribas-López , Nazanin Zand , Omorogieva Ojo , Martin John Snowden, Tony Kochhar（2022）。《A Systematic Review of the Effect of Centella asiatica on Wound Healing》。Switzerland：Int J Environ Res Public Health。
黃耆
由於黃耆的成分有諸多藥理作用，因此成為近來中藥研究的熱門題材，茲綜述近期研究文獻，提供未來研究的新趨勢：1.加速傷口修復機制。[1]
Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1. Astragaloside IV (AST) is one of the major active components extracted from Astragalus membranaceus. Transforming growth factor-β type II protein and COL1 mRNA decreased but MMP-1 and Smad7 levels increased in the photoaging model group, which was reversed by topical application of AST. AST prevents collagen reduction from UV irradiation in photoaging skin by improving TGF-β/Smad signaling suppression and inhibiting MMP-1, thus AST may be a potential agent against skin photoaging.（黃耆皂苷透過改善轉化生長因子訊號傳導抑制，抑制基質金屬蛋白酶來控制光老化皮膚中膠原蛋白的減少。黃耆皂苷是從黃耆中提取的主要活性成分之一。光老化模型組中轉化生長因子-βII型蛋白和COL1mRNA 降低，但MMP-1和Smad7水準升高，局部應用黃耆皂苷可以逆轉這種情況。黃耆皂苷透過改善TGF-β/Smad訊號傳導抑制和抑制MMP-1來防止光老化皮膚中紫外線照射導致的膠原蛋白減少，因此黃耆皂苷可能是抗皮膚光老化的潛在藥物。[2]
出處:
[1]衛生福利部國家中藥研究院圖書館編輯（2011）《黃耆的藥理成份研究新知》。台北：衛生福利部國家中藥研究院
[2]Bin Chen, Ran Li, Ning Yan, Gang Chen, Wen Qian, Hui-Li Jiang, Chao Ji, Zhi-Gang Bi（2015）《Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1》。Greece：Spandidos Publications
三七根
Saponins of KRG can protect the skin from the harmful effects of particulate matter exposure by reducing levels of ROS, leptin, inflammatory cytokines, and melanin. (韓國人蔘皂苷可以透過降低自由基、激素、發炎細胞因子和黑色素的水平來保護皮膚免受空氣懸浮微粒暴露的有害影響。[1]
In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds. (在這項研究中，我們透過組織學分析研究了人參總皂苷對皮膚傷口癒合過程的影響。 結果顯示，第3天到第7天，人參總皂苷治療組的傷口面積比對照組更小，角質細胞遷移率更高。與對照組相比，人參總皂苷治療組的發炎細胞在第 1天和第3天有所減少。在第3至5天，人參總皂苷治療組的傷口收縮大於對照組，且在傷口癒合過程中，人參總皂苷治療組的膠原沉積高於對照組。結果表明，人參總皂苷在用於治療皮膚傷口時具有有益作用。[2]
出處:
[1]Ik Jun Moon, Woo Hyeong Kim, Su Yeon Kim, Jeong Hyeon Lee, Hanju Yoo, Seunghyun Bang, Youngsup Song, Sung Eun Chang（2022）《Saponins of Korean Red Ginseng May Protect Human Skin from Adipokine-Associated Inflammation and Pigmentation Resulting from Particulate Matter Exposure》。Switzerland：MDPI
[2]Young Soo Kim, Ik-Hyun Cho, Moon-Jin Jeong, Soon-Jeong Jeong, Seung Yeol Nah, Young-Sik Cho, Seung Hyun Kim, Ara Go, Se Eun Kim, Seong Soo Kang, Chang Jong Moon, Jong Choon Kim, Sung Ho Kim, Chun Sik Bae（2011）《Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing 》。Korea：Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine, Gwangju
